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Progenitor cells from human brain after death

Author

Listed:
  • Theo D. Palmer

    (The Salk Institute, Laboratory of Genetics
    Stanford University)

  • Philip H. Schwartz

    (Children's Hospital of Orange County, Brain and Tissue Bank for Developmental Disorders)

  • Philippe Taupin

    (The Salk Institute, Laboratory of Genetics)

  • Brian Kaspar

    (The Salk Institute, Laboratory of Genetics)

  • Stuart A. Stein

    (Children's Hospital of Orange County, Brain and Tissue Bank for Developmental Disorders)

  • Fred H. Gage

    (The Salk Institute, Laboratory of Genetics)

Abstract

Culturing neural progenitor cells from the adult rodent brain has become routine1,2 and is also possible from human fetal tissue3,4, but expansion of these cells from postnatal and adult human tissue, although preferred for ethical reasons, has encountered problems5,6,7,8. Here we describe the isolation and successful propagation of neural progenitor cells from human postmortem tissues and surgical specimens. Although the relative therapeutic merits of adult and fetal progenitor cells still need to be assessed, our results may extend the application of these progenitor cells in the treatment of neurodegenerative diseases.

Suggested Citation

  • Theo D. Palmer & Philip H. Schwartz & Philippe Taupin & Brian Kaspar & Stuart A. Stein & Fred H. Gage, 2001. "Progenitor cells from human brain after death," Nature, Nature, vol. 411(6833), pages 42-43, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6833:d:10.1038_35075141
    DOI: 10.1038/35075141
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