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A physical map of human chromosome 14

Author

Listed:
  • Thomas Brüls

    (Genoscope and CNRS UMR 8030)

  • Gabor Gyapay

    (Genoscope and CNRS UMR 8030)

  • Jean-Louis Petit

    (Genoscope and CNRS UMR 8030)

  • François Artiguenave

    (Genoscope and CNRS UMR 8030)

  • Virginie Vico

    (Genoscope and CNRS UMR 8030)

  • Shizen Qin

    (Multimegabase Sequencing Center, The Institute for Systems Biology)

  • Aye Mon Tin-Wollam

    (Washington University Genome Sequencing Center)

  • Corinne Da Silva

    (Genoscope and CNRS UMR 8030)

  • Delphine Muselet

    (Genoscope and CNRS UMR 8030)

  • Delphine Mavel

    (Genoscope and CNRS UMR 8030)

  • Eric Pelletier

    (Genoscope and CNRS UMR 8030)

  • Michael Levy

    (Genoscope and CNRS UMR 8030)

  • Asao Fujiyama

    (RIKEN Genome Sciences Center)

  • Fumihiko Matsuda

    (Centre National de Genotypage)

  • Richard Wilson

    (Washington University Genome Sequencing Center)

  • Lee Rowen

    (Multimegabase Sequencing Center, The Institute for Systems Biology)

  • Leroy Hood

    (Multimegabase Sequencing Center, The Institute for Systems Biology)

  • Jean Weissenbach

    (Genoscope and CNRS UMR 8030)

  • William Saurin

    (Genoscope and CNRS UMR 8030)

  • Roland Heilig

    (Genoscope and CNRS UMR 8030)

Abstract

We report the construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14. Clone overlap information to assemble the map was derived by comparing fully sequenced clones with a database of clone end sequences1,2 (sequence tag connector strategy). We selected homogeneously distributed seed points using an auxiliary high-resolution radiation hybrid map comprising 1,895 distinct positions. The high long-range continuity and low redundancy of the tiling path indicates that the sequence tag connector approach compares favourably with alternative mapping strategies.

Suggested Citation

  • Thomas Brüls & Gabor Gyapay & Jean-Louis Petit & François Artiguenave & Virginie Vico & Shizen Qin & Aye Mon Tin-Wollam & Corinne Da Silva & Delphine Muselet & Delphine Mavel & Eric Pelletier & Michae, 2001. "A physical map of human chromosome 14," Nature, Nature, vol. 409(6822), pages 947-948, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057177
    DOI: 10.1038/35057177
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