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Matrix proteins can generate the higher order architecture of the Golgi apparatus

Author

Listed:
  • Joachim Seemann

    (Yale University School of Medicine)

  • Eija Jokitalo

    (Institute of Biotechnology, Electron Microscopy Unit, Biocenter 1
    University of Helsinki)

  • Marc Pypaert

    (Yale University School of Medicine)

  • Graham Warren

    (Yale University School of Medicine)

Abstract

The Golgi apparatus in animal cells comprises a reticulum of linked stacks in the pericentriolar and often in the juxtanuclear regions of the cell1. The unique architecture of this organelle is thought to depend on the cytoskeleton2 and cytoplasmic matrix proteins3,4—the best characterized being the golgin family of fibrous, coiled-coil proteins and the GRASP family of stacking proteins5,6,7,8,9,10. Here we show that these matrix proteins can be separated from oligosaccharide-modifying enzymes in the Golgi stack without affecting their ability to form a ribbon-like reticulum in the correct location near to the nucleus. Our data suggest that the Golgi is a structural scaffold that can exist independently of, but is normally populated by, the enzyme-containing membranes that modify transiting cargo. This new concept of the Golgi further indicates that the Golgi may be an autonomous organelle rather than one that is in simple dynamic equilibrium with the endoplasmic reticulum.

Suggested Citation

  • Joachim Seemann & Eija Jokitalo & Marc Pypaert & Graham Warren, 2000. "Matrix proteins can generate the higher order architecture of the Golgi apparatus," Nature, Nature, vol. 407(6807), pages 1022-1026, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6807:d:10.1038_35039538
    DOI: 10.1038/35039538
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