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Formation of endothelial cell networks

Author

Listed:
  • Gabriel Helmlinger

    (Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Mitsuhiro Endo

    (Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Napoleone Ferrara

    (Genentech)

  • Lynn Hlatky

    (Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School)

  • Rakesh K. Jain

    (Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

Abstract

The growth factor VEGF (vascular endothelial growth factor) promotes the formation of blood vessels in a process known as angiogenesis by inducing the proliferation and migration of endothelial cells1. We show here that VEGF has another proangiogenic function — it can stimulate the elongation, network formation and branching of non-proliferating endothelial cells in culture that are deprived of oxygen and nutrients. As endothelial cells in tumours are exposed to chronic or intermittent hypoxic conditions2,3, we propose that autocrine endothelial VEGF contributes to the formation of blood vessels in a tumour and promotes its survival.

Suggested Citation

  • Gabriel Helmlinger & Mitsuhiro Endo & Napoleone Ferrara & Lynn Hlatky & Rakesh K. Jain, 2000. "Formation of endothelial cell networks," Nature, Nature, vol. 405(6783), pages 139-141, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6783:d:10.1038_35012132
    DOI: 10.1038/35012132
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