IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v402y1999i6760d10.1038_46555.html
   My bibliography  Save this article

The dynamics of chromosome evolution in birds and mammals

Author

Listed:
  • David W. Burt

    (Roslin Institute (Edinburgh))

  • Charlotte Bruley

    (Roslin Institute (Edinburgh))

  • Ian C. Dunn

    (Roslin Institute (Edinburgh))

  • Cheryl T. Jones

    (Roslin Institute (Edinburgh))

  • Anne Ramage

    (Roslin Institute (Edinburgh))

  • Andy S. Law

    (Roslin Institute (Edinburgh))

  • David R. Morrice

    (Roslin Institute (Edinburgh))

  • Ian R. Paton

    (Roslin Institute (Edinburgh))

  • Jacqueline Smith

    (Roslin Institute (Edinburgh))

  • Dawn Windsor

    (Roslin Institute (Edinburgh))

  • Alexei Sazanov

    (Lehrstuhl fur Tierzucht, TUM, Freising)

  • Ruedi Fries

    (Lehrstuhl fur Tierzucht, TUM, Freising)

  • David Waddington

    (Roslin Institute (Edinburgh))

Abstract

Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution1. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years1,2,3,4. On the basis of these rates we would expect 84 to 600 conserved segments in a chicken comparison with human or mouse. Here we build comparative maps between these species and estimate that numbers of conserved segments are in the lower part of this range. We conclude that the organization of the human genome is closer to that of the chicken than the mouse and by adding comparative mapping results from a range of vertebrates, we identify three possible phases of chromosome evolution. The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates.

Suggested Citation

  • David W. Burt & Charlotte Bruley & Ian C. Dunn & Cheryl T. Jones & Anne Ramage & Andy S. Law & David R. Morrice & Ian R. Paton & Jacqueline Smith & Dawn Windsor & Alexei Sazanov & Ruedi Fries & David , 1999. "The dynamics of chromosome evolution in birds and mammals," Nature, Nature, vol. 402(6760), pages 411-413, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_46555
    DOI: 10.1038/46555
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/46555
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/46555?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_46555. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.