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Extracellular sodium regulates airway ciliary motility by inhibiting a P2X receptor

Author

Listed:
  • Weiyuan Ma

    (Ben-Gurion University of the Negev)

  • Alon Korngreen

    (Ben-Gurion University of the Negev
    Max-Planck Institut für medizinische Forschung Abteilung Zellphysiologie)

  • Natalya Uzlaner

    (Ben-Gurion University of the Negev)

  • Zvi Priel

    (Ben-Gurion University of the Negev)

  • Shai D. Silberberg

    (Ben-Gurion University of the Negev)

Abstract

The mucociliary system is responsible for clearing inhaled particles and pathogens from the airways. This important task is performed by the beating of cilia and the consequent movement of mucus from the lungs to the upper airways1,2. Because ciliary motility is enhanced by elevated intracellular calcium concentrations, inhibition of calcium influx could lead to disease by jeopardizing mucociliary clearance. Several hormones and neurotransmitters stimulate ciliary motility, one of the most potent of which is extracellular ATP (ATPo)1, which acts by releasing calcium ions from internal stores and by activating calcium influx3,4,5. Here we show that, in airway ciliated cells, extracellular sodium ions (Nao+) specifically and competitively inhibit an ATPo-gated channel that is permeable to calcium ions, and thereby attenuate ATPo-induced ciliary motility. Our finding points to a physiological role for Nao+ in ciliary function, and indicates that mucociliary clearance might be improved in respiratory disorders such as chronic bronchitis and cystic fibrosis by decreasing the sodium concentration of the airway surface fluid in which the cilia are bathed.

Suggested Citation

  • Weiyuan Ma & Alon Korngreen & Natalya Uzlaner & Zvi Priel & Shai D. Silberberg, 1999. "Extracellular sodium regulates airway ciliary motility by inhibiting a P2X receptor," Nature, Nature, vol. 400(6747), pages 894-897, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6747:d:10.1038_23743
    DOI: 10.1038/23743
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