IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v400y1999i6744d10.1038_23040.html
   My bibliography  Save this article

Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses

Author

Listed:
  • Fleur L. Kidd

    (MRC Centre for Synaptic Plasticity, University of Bristol)

  • John T. R. Isaac

    (MRC Centre for Synaptic Plasticity, University of Bristol)

Abstract

Most of the fast excitatory synaptic transmission in the mammalian brain is mediated by ionotrophic glutamate receptors, of which there are three subtypes: AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate), NMDA (N -methyl-D-aspartate) and kainate. Although kainate-receptor subunits (GluR5–7, KA1 and 2) are widely expressed in the mammalian central nervous system1,2, little is known about their function. The development of pharmacological agents that distinguish between AMPA and kainate receptors has now allowed the functions of kainate receptors to be investigated3,4. The modulation of synaptic transmission by kainate receptors5,6,7 and their synaptic activation8,9,10,11,12,13,14 in a variety of brain regions have been reported. The expression of kainate receptor subunits is developmentally regulated1,2 but their role in plasticity and development is unknown. Here we show that developing thalamocortical synapses express postsynaptic kainate receptors as well as AMPA receptors; however, the two receptor subtypes do not co-localize. During the critical period for experience-dependent plasticity, the kainate-receptor contribution to transmission decreases; a similar decrease occurs when long-term potentiation is induced in vitro. This indicates that during development there is activity-dependent regulation of the expression of kainate receptors at thalamocortical synapses.

Suggested Citation

  • Fleur L. Kidd & John T. R. Isaac, 1999. "Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses," Nature, Nature, vol. 400(6744), pages 569-573, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6744:d:10.1038_23040
    DOI: 10.1038/23040
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/23040
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/23040?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:400:y:1999:i:6744:d:10.1038_23040. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.