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Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

Author

Listed:
  • Colleen E. Clancy

    (Cardiac Bioelectricity Research and Training Center
    Case Western Reserve University)

  • Yoram Rudy

    (Cardiac Bioelectricity Research and Training Center
    Department of Biomedical Engineering
    Case Western Reserve University)

Abstract

Advances in genetics and molecular biology have provided an extensive body of information on the structure and function of the elementary building blocks of living systems. Genetic defects in membrane ion channels can disrupt the delicate balance of dynamic interactions between the ion channels and the cellular environment, leading to altered cell function1,2,3. As ion-channel defects are typically studied in isolated expression systems, away from the cellular environment where they function physiologically, a connection between molecular findings and the physiology and pathophysiology of the cell is rarely established. Here we describe a single-channel-based Markovian modelling approach that bridges this gap. We achieve this by determining the cellular arrhythmogenic consequences of a mutation in the cardiac sodium channel that can lead to a clinical arrhythmogenic disorder (the long-QT syndrome) and sudden cardiac death.

Suggested Citation

  • Colleen E. Clancy & Yoram Rudy, 1999. "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia," Nature, Nature, vol. 400(6744), pages 566-569, August.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6744:d:10.1038_23034
    DOI: 10.1038/23034
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