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Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

Author

Listed:
  • Takashi Adachi-Yamada

    (Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation)

  • Konomi Fujimura-Kamada

    (Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation)

  • Yasuyoshi Nishida

    (Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation)

  • Kunihiro Matsumoto

    (Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation)

Abstract

Distinct and evolutionarily conserved signal-transduction cascades mediate the survival or death of cells during development. The c-Jun amino-terminal kinases (JNKs) of the mitogen-activated protein kinase superfamily are involved in apoptotic signalling in various cultured cells1. However, the role of the JNK pathway in development is less well understood. In Drosophila, Decapentaplegic (Dpp; a homologue of transforming growth factor-β) and Wingless (Wg; a Wnt homologue) proteins are secretory morphogens that act cooperatively to induce formation of the proximodistal axis of appendages2,3,4,5,6,7. Here we show that either decreased Dpp signalling in the distal wing cells or increased Dpp signalling in the proximal wing cells causes apoptosis. Inappropriate levels of Dpp signalling lead to aberrant morphogenesis in the respective wing zones, and these apoptotic zones are also determined by the strength of the Wg signal. Our results indicate that distortion of the positional information determined by Dpp and Wg signalling gradients leads to activation of the JNK apoptotic pathway, and the consequent induction of cell death thereby maintains normal morphogenesis.

Suggested Citation

  • Takashi Adachi-Yamada & Konomi Fujimura-Kamada & Yasuyoshi Nishida & Kunihiro Matsumoto, 1999. "Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing," Nature, Nature, vol. 400(6740), pages 166-169, July.
    • Handle: RePEc:nat:nature:v:400:y:1999:i:6740:d:10.1038_22112
    DOI: 10.1038/22112
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    Cited by:

    1. Katerina Karkali & Timothy E. Saunders & George Panayotou & Enrique Martín-Blanco, 2023. "JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Shinya Matsuda & Jonas V. Schaefer & Yusuke Mii & Yutaro Hori & Dimitri Bieli & Masanori Taira & Andreas Plückthun & Markus Affolter, 2021. "Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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