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DNA damage enables p73

Author

Listed:
  • Eileen White

    (Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Cancer Institute of New Jersey, and Rutgers University)

  • Carol Prives

    (Columbia University, Sherman Fairchild Center for the Life Sciences)

Abstract

The'guardian of the genome', p53, is the best-known tumour-suppressor gene. Two other proteins — p63 and p73 — have similar sequences and properties to p53. But p53 is the only one to be induced by DNA damage. Or at least it was. A new study shows that, in fact, p73 is also induced by DNA damage via the non-receptor tyrosine kinase c-Abl.

Suggested Citation

  • Eileen White & Carol Prives, 1999. "DNA damage enables p73," Nature, Nature, vol. 399(6738), pages 735-737, June.
    • Handle: RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_21539
    DOI: 10.1038/21539
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