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Has the smart bomb been defused?

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  • Steven P. Linke

    (the Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health)

Abstract

Most cancer therapies aim to destroy tumour cells, leaving the surrounding normal cells untouched. This is the basis of one treatment, involving a mutated adenovirus that is thought to destroy only those cells that lack the tumour-suppressor protein p53. But new research indicates that the adenovirus may actually require p53 to replicate, meaning that it would instead target healthy cells.

Suggested Citation

  • Steven P. Linke, 1998. "Has the smart bomb been defused?," Nature, Nature, vol. 395(6697), pages 13-15, September.
    • Handle: RePEc:nat:nature:v:395:y:1998:i:6697:d:10.1038_25595
    DOI: 10.1038/25595
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