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Domains of rasGAP and rhoGAP are related

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  • Benjamin Bax

    (Birkbeck College)

Abstract

Guanine-nucleotide-binding (G) proteins are ‘switched off’ by the hydrolysis of their bound GTP. The GTP bound to the G protein Ras is hydrolysed intrinsically at a very slow rate1, so, in vivo, Ras is turned off by GTPase-activating proteins (GAPs). The structures of GTPase-activating domains (GAP domains), which usually occur as parts of larger proteins, indicate that the Ras and Rho families of small G proteins and their GAPs evolved in parallel.

Suggested Citation

  • Benjamin Bax, 1998. "Domains of rasGAP and rhoGAP are related," Nature, Nature, vol. 392(6675), pages 447-447, April.
  • Handle: RePEc:nat:nature:v:392:y:1998:i:6675:d:10.1038_33040
    DOI: 10.1038/33040
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