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Binary specification of the embryonic lineage in Caenorhabditis elegans

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  • Titus Kaletta

    (Max-Planck-Institut für Biochemie)

  • Heinke Schnabel

    (Max-Planck-Institut für Biochemie)

  • Ralf Schnabel

    (Max-Planck-Institut für Biochemie)

Abstract

In Caenorhabditis elegans, the early embryo contains five somatic founder cells (known as AB, MS, E, C and D) which give rise to very different lineages. Two simply produce twenty intestinal (E) or muscle (D) cells each, whereas the remainder produce a total of 518 cells which collectively contribute in a complex pattern to a variety of tissues1. A central problem in embryonic development is to understand how the developmental potential of blastomeres is restricted to permit the terminal expression of such complex differentiation patterns. Here we identify a gene, lit-1, that appears to play a central role in controlling the asymmetry of cell division during embryogenesis in C. elegans. Mutants in lit-1 suggest that its product controls up to six consecutive binary switches which cause one of the two equivalent cells produced at each cleavage to assume a posterior fate. Most blastomere identities in C. elegans may therefore stem from a process of stepwise binary diversification.

Suggested Citation

  • Titus Kaletta & Heinke Schnabel & Ralf Schnabel, 1997. "Binary specification of the embryonic lineage in Caenorhabditis elegans," Nature, Nature, vol. 390(6657), pages 294-298, November.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6657:d:10.1038_36869
    DOI: 10.1038/36869
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