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Reading, writing and redesigning

Author

Listed:
  • Michael Gro

    (the Oxford Centre for Molecular Sciences)

  • Kevin W. Plaxco

    (the Oxford Centre for Molecular Sciences
    University of Washington)

Abstract

In 1994, George Rose and Trevor Creamer proposed the ‘Paracelsus challenge’, offering $1,000 to the first person who could show a pair of proteins that have different topologies, yet no less than 50% sequence identity. The challenge has now been met by a group who have created the aptly named Janus protein. Janus shares 50% sequence identity with the B1 domain of the Streptococcal protein G - which is mainly beta-sheet - yet it folds into a helical structure that resembles the four-helix-bundle protein Rop.

Suggested Citation

  • Michael Gro & Kevin W. Plaxco, 1997. "Reading, writing and redesigning," Nature, Nature, vol. 388(6641), pages 419-420, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6641:d:10.1038_41204
    DOI: 10.1038/41204
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