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Mad about SMADs

Author

Listed:
  • Jeff Wrans

    (The Hospital for Sick Children)

  • Tony Pawson

    (Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital)

Abstract

Signalling through the transforming growth factor-beta (TGF-beta) requires the so-called Smad proteins, and two papers now show how the Smads work. TGF-beta binds to its receptor, which then activates Smad2 to form a transcriptionally active complex with Smad4. But the crystal structure of Smad4 shows that its carboxy-terminal domain can join up with its amino-terminal domain, to prevent the formation of a complex and, hence, to inhibit TGF-beta- mediated signalling.

Suggested Citation

  • Jeff Wrans & Tony Pawson, 1997. "Mad about SMADs," Nature, Nature, vol. 388(6637), pages 28-29, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6637:d:10.1038_40290
    DOI: 10.1038/40290
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