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An endothelial receptor for oxidized low-density lipoprotein

Author

Listed:
  • Tatsuya Sawamura

    (Kyoto University)

  • Noriaki Kume

    (Kyoto University)

  • Takuma Aoyama

    (Kyoto University)

  • Hideaki Moriwaki

    (Kyoto University)

  • Hajime Hoshikawa

    (Kyoto University)

  • Yuichi Aiba

    (Kyoto University)

  • Takeshi Tanaka

    (Japan Red Cross Saitama Branch)

  • Soichi Miwa

    (Kyoto University)

  • Yoshimoto Katsura

    (Kyoto University)

  • Toru Kita

    (Kyoto University)

  • Tomoh Masaki

    (Kyoto University)

Abstract

Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis1–4, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis5–7. Vascular endothelial cells in culture8,9 and in vivo10,11 internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors12–15. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.

Suggested Citation

  • Tatsuya Sawamura & Noriaki Kume & Takuma Aoyama & Hideaki Moriwaki & Hajime Hoshikawa & Yuichi Aiba & Takeshi Tanaka & Soichi Miwa & Yoshimoto Katsura & Toru Kita & Tomoh Masaki, 1997. "An endothelial receptor for oxidized low-density lipoprotein," Nature, Nature, vol. 386(6620), pages 73-77, March.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6620:d:10.1038_386073a0
    DOI: 10.1038/386073a0
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