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HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

Author

Listed:
  • Takumi Kawabe

    (Washington University School of Medicine)

  • Anthony J. Muslin

    (Washington University School of Medicine)

  • Stanley J. Korsmeyer

    (Washington University School of Medicine)

Abstract

Hoxl1 is an orphan homeobox gene that controls the genesis of the spleen1. HOX11 is also oncogenic, having been isolated from a chromosomal breakpoint in human T-cell leukaemia2–4. Transgenic mice that redirected HOX11 to the thymus demonstrated cell-cycle aberration and progression to malignancy5. We observed that the protein HOX11 interacted with protein serine-threonine phosphatase 2A catalytic subunit (PP2AC), as well as protein phosphatase 1 (PP1C) in mammalian cells. Inhibition of PP2A can regulate the cell cycle and control the activation of maturation-promoting factor in Xenopus oocytes6. Microinjection of HOX11 into Xenopus oocytes arrested at the G2 phase of the cell cycle promoted progression to the M phase. G2 arrest can be induced by λ-irradiation, but is eliminated by expression of HOX11 within a T-cell line. Thus HOX11 is a cellular oncogene that targets PP2A and PP1, both of which are targets for oncogenic viruses and chemical tumour promoters7,8. This interaction suggests a mechanism by which a homeobox can alter the cell cycle.

Suggested Citation

  • Takumi Kawabe & Anthony J. Muslin & Stanley J. Korsmeyer, 1997. "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint," Nature, Nature, vol. 385(6615), pages 454-458, January.
    • Handle: RePEc:nat:nature:v:385:y:1997:i:6615:d:10.1038_385454a0
    DOI: 10.1038/385454a0
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