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Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

Author

Listed:
  • Leandros Arvanitakis

    (Cornell University Medical College)

  • Elizabeth Geras-Raaka

    (Cornell University Medical College)

  • Anjali Varma

    (Cornell University Medical College)

  • Marvin C. Gershengorn

    (Cornell University Medical College)

  • Ethel Cesarman

    (Cornell University Medical College)

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8, or HHV 8) is a virus that is consistently present in Kaposi's sarcoma1,2 and in primary-effusion (body-cavity-based) lymphomas3, malignancies that occur frequently, but not exclusively, in AIDS patients. KSHV is a gamma herpes-virus with homology to herpesvirus Saimiri and Epstein-Barr virus1,4, both of which can transform lymphocytes5. Cloning of a KSHV genome fragment revealed the presence of an open reading frame encoding a putative G-protein-coupled receptor6 that is homologous to a G-protein-coupled receptor encoded by herpes-virus Saimiri7,8 and to human interleukin-8 receptors9,10. Here we show that the KSHV G-protein-coupled receptor is a bona fide signalling receptor which has constitutive (agonist-independent) activity in the phosphoinositide–inositoltrisphosphate–protein kinase C pathway. Furthermore, the KSHV G-protein-coupled receptor stimulates cellular proliferation, making it a candidate viral oncogene.

Suggested Citation

  • Leandros Arvanitakis & Elizabeth Geras-Raaka & Anjali Varma & Marvin C. Gershengorn & Ethel Cesarman, 1997. "Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation," Nature, Nature, vol. 385(6614), pages 347-350, January.
    • Handle: RePEc:nat:nature:v:385:y:1997:i:6614:d:10.1038_385347a0
    DOI: 10.1038/385347a0
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