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Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

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Listed:
  • Soyeon Kim

    (Sungkyunkwan University, Samsung Medical Center
    Seoul National University Bundang Hospital
    Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Kiwon Kim

    (Hallym University College of Medicine)

  • Mi Yeong Hwang

    (Division of Genome Science, Department of Precision Medicine, National Institute of Health)

  • Hyunwoong Ko

    (Seoul National University)

  • Sang-Hyuk Jung

    (Sungkyunkwan University, Samsung Medical Center)

  • Injeong Shim

    (Sungkyunkwan University, Samsung Medical Center)

  • Soojin Cha

    (Sungkyunkwan University, Samsung Medical Center)

  • Hyewon Lee

    (Soonchunhyang University)

  • Beomsu Kim

    (Sungkyunkwan University, Samsung Medical Center)

  • Joohyun Yoon

    (Seoul National University Bundang Hospital)

  • Tae Hyon Ha

    (Seoul National University Bundang Hospital)

  • Doh Kwan Kim

    (Sungkyunkwan University School of Medicine)

  • Jinho Kim

    (Seoul National University Bundang Hospital)

  • Woong-Yang Park

    (Sungkyunkwan University School of Medicine)

  • Aysu Okbay

    (Vrije Universiteit Amsterdam)

  • Bong-Jo Kim

    (Division of Genome Science, Department of Precision Medicine, National Institute of Health)

  • Young Jin Kim

    (Division of Genome Science, Department of Precision Medicine, National Institute of Health)

  • Woojae Myung

    (Seoul National University Bundang Hospital)

  • Hong-Hee Won

    (Sungkyunkwan University, Samsung Medical Center
    Sungkyunkwan University School of Medicine)

Abstract

Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.

Suggested Citation

  • Soyeon Kim & Kiwon Kim & Mi Yeong Hwang & Hyunwoong Ko & Sang-Hyuk Jung & Injeong Shim & Soojin Cha & Hyewon Lee & Beomsu Kim & Joohyun Yoon & Tae Hyon Ha & Doh Kwan Kim & Jinho Kim & Woong-Yang Park , 2022. "Shared genetic architectures of subjective well-being in East Asian and European ancestry populations," Nature Human Behaviour, Nature, vol. 6(7), pages 1014-1026, July.
    • Handle: RePEc:nat:nathum:v:6:y:2022:i:7:d:10.1038_s41562-022-01343-5
    DOI: 10.1038/s41562-022-01343-5
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