Author
Listed:
- Yaqiong Xiao
(University of California, San Diego)
- Teresa H. Wen
(University of California, San Diego)
- Lauren Kupis
(University of Miami)
- Lisa T. Eyler
(University of California, San Diego
VA San Diego Healthcare System)
- Disha Goel
(University of California, San Diego)
- Keith Vaux
(UC San Diego Health Physician Network)
- Michael V. Lombardo
(Istituto Italiano di Tecnologia
University of Cambridge)
- Nathan E. Lewis
(University of California, San Diego)
- Karen Pierce
(University of California, San Diego)
- Eric Courchesne
(University of California, San Diego)
Abstract
Affective speech, including motherese, captures an infant’s attention and enhances social, language and emotional development. Decreased behavioural response to affective speech and reduced caregiver–child interactions are early signs of autism in infants. To understand this, we measured neural responses to mild affect speech, moderate affect speech and motherese using natural sleep functional magnetic resonance imaging and behavioural preference for motherese using eye tracking in typically developing toddlers and those with autism. By combining diverse neural–clinical data using similarity network fusion, we discovered four distinct clusters of toddlers. The autism cluster with the weakest superior temporal responses to affective speech and very poor social and language abilities had reduced behavioural preference for motherese, while the typically developing cluster with the strongest superior temporal response to affective speech showed the opposite effect. We conclude that significantly reduced behavioural preference for motherese in autism is related to impaired development of temporal cortical systems that normally respond to parental affective speech.
Suggested Citation
Yaqiong Xiao & Teresa H. Wen & Lauren Kupis & Lisa T. Eyler & Disha Goel & Keith Vaux & Michael V. Lombardo & Nathan E. Lewis & Karen Pierce & Eric Courchesne, 2022.
"Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD,"
Nature Human Behaviour, Nature, vol. 6(3), pages 443-454, March.
Handle:
RePEc:nat:nathum:v:6:y:2022:i:3:d:10.1038_s41562-021-01237-y
DOI: 10.1038/s41562-021-01237-y
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nathum:v:6:y:2022:i:3:d:10.1038_s41562-021-01237-y. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.