IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07688-8.html
   My bibliography  Save this article

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

Author

Listed:
  • Heuijoon Park

    (Columbia University
    Columbia University
    Columbia University
    University of Minnesota)

  • Sonali Lad

    (University of Minnesota)

  • Kelsey Boland

    (University of Minnesota)

  • Kelly Johnson

    (University of Minnesota)

  • Nyssa Readio

    (University of Minnesota)

  • Guangchun Jin

    (Columbia University)

  • Samuel Asfaha

    (Columbia University)

  • Kelly S. Patterson

    (Columbia University)

  • Ashok Singh

    (University of Minnesota)

  • Xiangdong Yang

    (Columbia University)

  • Douglas Londono

    (The State University of New Jersey)

  • Anupama Singh

    (University of Minnesota)

  • Carol Trempus

    (National Institute of Environmental Health Sciences)

  • Derek Gordon

    (The State University of New Jersey)

  • Timothy C. Wang

    (Columbia University)

  • Rebecca J. Morris

    (Columbia University
    Columbia University
    University of Minnesota)

Abstract

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Lineage-depleted BMCs migrated towards High Mobility Group Box 1 (HMGB1) protein and epidermal KCs in ex vivo invasion assays. Naive female mice receiving BMTs from DMBA-treated donors developed benign and malignant lesions after TPA promotion alone. We conclude that BMDECs contribute to the development of papillomas and dysplasia, demonstrating a systemic contribution to these lesions. Furthermore, carcinogen-exposed BMCs can initiate benign and malignant lesions upon tumor promotion. Ultimately, these findings may suggest targets for treatment of non-melanoma skin cancers.

Suggested Citation

  • Heuijoon Park & Sonali Lad & Kelsey Boland & Kelly Johnson & Nyssa Readio & Guangchun Jin & Samuel Asfaha & Kelly S. Patterson & Ashok Singh & Xiangdong Yang & Douglas Londono & Anupama Singh & Carol , 2018. "Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07688-8
    DOI: 10.1038/s41467-018-07688-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07688-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-07688-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07688-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.