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Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

Author

Listed:
  • Linda Wampach

    (University of Luxembourg
    Laboratoire National de Santé)

  • Anna Heintz-Buschart

    (University of Luxembourg
    German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
    Helmholtz Centre for Environmental Research GmbH – UFZ)

  • Joëlle V. Fritz

    (University of Luxembourg
    Centre Hospitalier de Luxembourg)

  • Javier Ramiro-Garcia

    (University of Luxembourg)

  • Janine Habier

    (University of Luxembourg)

  • Malte Herold

    (University of Luxembourg)

  • Shaman Narayanasamy

    (University of Luxembourg
    Megeno S.A.)

  • Anne Kaysen

    (University of Luxembourg
    Centre Hospitalier de Luxembourg)

  • Angela H. Hogan

    (Integrated BioBank of Luxembourg)

  • Lutz Bindl

    (Centre Hospitalier de Luxembourg)

  • Jean Bottu

    (Centre Hospitalier de Luxembourg)

  • Rashi Halder

    (University of Luxembourg)

  • Conny Sjöqvist

    (KTH Royal Institute of Technology, Science for Life Laboratory, School of Biotechnology, Division of Gene Technology
    Åbo Akademi University)

  • Patrick May

    (University of Luxembourg)

  • Anders F. Andersson

    (KTH Royal Institute of Technology, Science for Life Laboratory, School of Biotechnology, Division of Gene Technology)

  • Carine Beaufort

    (Centre Hospitalier de Luxembourg)

  • Paul Wilmes

    (University of Luxembourg)

Abstract

The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. We identify differences in encoded functions between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis. We link these enriched functions to individual-specific strains, which are transmitted from mothers to neonates in case of VD. The stimulation of primary human immune cells with LPS isolated from early stool samples of VD neonates results in higher levels of tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results support that CSD disrupts mother-to-neonate transmission of specific microbial strains, linked functional repertoires and immune-stimulatory potential during a critical window for neonatal immune system priming.

Suggested Citation

  • Linda Wampach & Anna Heintz-Buschart & Joëlle V. Fritz & Javier Ramiro-Garcia & Janine Habier & Malte Herold & Shaman Narayanasamy & Anne Kaysen & Angela H. Hogan & Lutz Bindl & Jean Bottu & Rashi Hal, 2018. "Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07631-x
    DOI: 10.1038/s41467-018-07631-x
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    Cited by:

    1. Gwinyai Masukume & Ali S Khashan & Susan M B Morton & Philip N Baker & Louise C Kenny & Fergus P McCarthy, 2019. "Caesarean section delivery and childhood obesity in a British longitudinal cohort study," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-13, October.
    2. repec:plo:pone00:0221379 is not listed on IDEAS
    3. Noriaki Oguri & Chie Kobayashi & Yuri Ozawa & Toshihiko Kimura & Yuu Nishinarita & Haruka Wada & Nobuki Nemoto & Masami Narita & Shinji Tanigaki & Tomoko Hanawa & Jun Miyoshi & Tadakazu Hisamatsu, 2025. "Vaginal Lactobacillus crispatus in early pregnancy associates with favorable gestational outcomes in a Japanese maternal-neonatal microbiome cohort," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    4. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.
    5. Laura Nies & Susheel Bhanu Busi & Mina Tsenkova & Rashi Halder & Elisabeth Letellier & Paul Wilmes, 2022. "Evolution of the murine gut resistome following broad-spectrum antibiotic treatment," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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