IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-07413-5.html
   My bibliography  Save this article

Entropy production rate is maximized in non-contractile actomyosin

Author

Listed:
  • Daniel S. Seara

    (Yale University
    Systems Biology Institute, Yale University)

  • Vikrant Yadav

    (Systems Biology Institute, Yale University
    Yale University)

  • Ian Linsmeier

    (Systems Biology Institute, Yale University
    Yale University)

  • A. Pasha Tabatabai

    (Systems Biology Institute, Yale University
    Yale University)

  • Patrick W. Oakes

    (University of Rochester)

  • S. M. Ali Tabei

    (University of Northern Iowa)

  • Shiladitya Banerjee

    (Institute for the Physics of Living Systems, University College London)

  • Michael P. Murrell

    (Yale University
    Systems Biology Institute, Yale University
    Yale University)

Abstract

The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton out-of-equilibrium, the role of myosin-driven active stresses in the accumulation and dissipation of mechanical energy is unclear. To investigate this, we synthesize an actomyosin material in vitro whose active stress content can tune the network from stable to contractile. Each increment in activity determines a characteristic spectrum of actin filament fluctuations which is used to calculate the total mechanical work and the production of entropy in the material. We find that the balance of work and entropy does not increase monotonically and the entropy production rate is maximized in the non-contractile, stable state of actomyosin. Our study provides evidence that the origins of entropy production and activity-dependent dissipation relate to disorder in the molecular interactions between actin and myosin.

Suggested Citation

  • Daniel S. Seara & Vikrant Yadav & Ian Linsmeier & A. Pasha Tabatabai & Patrick W. Oakes & S. M. Ali Tabei & Shiladitya Banerjee & Michael P. Murrell, 2018. "Entropy production rate is maximized in non-contractile actomyosin," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07413-5
    DOI: 10.1038/s41467-018-07413-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-07413-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-07413-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Camelia G. Muresan & Zachary Gao Sun & Vikrant Yadav & A. Pasha Tabatabai & Laura Lanier & June Hyung Kim & Taeyoon Kim & Michael P. Murrell, 2022. "F-actin architecture determines constraints on myosin thick filament motion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Agustin D. Pizarro & Claudio L. A. Berli & Galo J. A. A. Soler-Illia & Martín G. Bellino, 2022. "Droplets in underlying chemical communication recreate cell interaction behaviors," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07413-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.