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A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides

Author

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  • Daniel Meyer

    (University of Bern)

  • Harish Jangra

    (LMU München)

  • Fabian Walther

    (University of Bern)

  • Hendrik Zipse

    (LMU München)

  • Philippe Renaud

    (University of Bern)

Abstract

Radical fluorination has been known for a long time, but synthetic applications were severely limited by the hazardous nature of the first generation of reagents such as F2 and the strongly electrophilic nature of the second generation of reagents such as N-fluorobenzenesulfonimide (NFSI) and Selecfluor®. Here, we report the preparation, use and properties of N-fluoro-N-arylsulfonamides (NFASs), a class of fluorinating reagents suitable for radical fluorination under mild conditions. Their N–F bond dissociation energies (BDE) are 30–45 kJ mol−1 lower than the N–F BDE of the reagents of the second generation. This favors clean radical fluorination processes over undesired side reactions. The utility of NFASs is demonstrated by a metal-free radical hydrofluorination of alkenes including an efficient remote C–H fluorination via a 1,5-hydrogen atom transfer. NFASs have the potential to become the reagents of choice in many radical fluorination processes.

Suggested Citation

  • Daniel Meyer & Harish Jangra & Fabian Walther & Hendrik Zipse & Philippe Renaud, 2018. "A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07196-9
    DOI: 10.1038/s41467-018-07196-9
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