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The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

Author

Listed:
  • Taylor K. Soderborg

    (University of Colorado Anschutz Medical Campus)

  • Sarah E. Clark

    (University of Colorado Anschutz Medical Campus)

  • Christopher E. Mulligan

    (University of Colorado Anschutz Medical Campus)

  • Rachel C. Janssen

    (University of Colorado Anschutz Medical Campus)

  • Lyndsey Babcock

    (University of Colorado Anschutz Medical Campus)

  • Diana Ir

    (University of Colorado Anschutz Medical Campus)

  • Bridget Young

    (University of Colorado Anschutz Medical Campus
    University of Rochester School of Medicine and Dentistry)

  • Nancy Krebs

    (University of Colorado Anschutz Medical Campus)

  • Dominick J. Lemas

    (University of Colorado Anschutz Medical Campus
    University of Florida)

  • Linda K. Johnson

    (University of Colorado Anschutz Medical Campus)

  • Tiffany Weir

    (Colorado State University)

  • Laurel L. Lenz

    (University of Colorado Anschutz Medical Campus)

  • Daniel N. Frank

    (University of Colorado Anschutz Medical Campus)

  • Teri L. Hernandez

    (University of Colorado Anschutz Medical Campus
    University of Colorado Anschutz Medical Campus)

  • Kristine A. Kuhn

    (University of Colorado Anschutz Medical Campus)

  • Angelo D’Alessandro

    (University of Colorado Anschutz Medical Campus)

  • Linda A. Barbour

    (University of Colorado Anschutz Medical Campus
    University of Colorado Anschutz Medical Campus)

  • Karim C. El Kasmi

    (University of Colorado Anschutz Medical Campus)

  • Jacob E. Friedman

    (University of Colorado Anschutz Medical Campus
    University of Colorado Anschutz Medical Campus
    University of Colorado Anschutz Medical Campus)

Abstract

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant gut by microbes plays a critical role in establishing immunity and metabolic function. Here, we compare germ-free mice colonized with stool microbes (MB) from 2-week-old infants born to obese (Inf-ObMB) or normal-weight (Inf-NWMB) mothers. Inf-ObMB-colonized mice demonstrate increased hepatic gene expression for endoplasmic reticulum stress and innate immunity together with histological signs of periportal inflammation, a histological pattern more commonly reported in pediatric cases of NAFLD. Inf-ObMB mice show increased intestinal permeability, reduced macrophage phagocytosis, and dampened cytokine production suggestive of impaired macrophage function. Furthermore, exposure to a Western-style diet in Inf-ObMB mice promotes excess weight gain and accelerates NAFLD. Overall, these results provide functional evidence supporting a causative role of maternal obesity-associated infant dysbiosis in childhood obesity and NAFLD.

Suggested Citation

  • Taylor K. Soderborg & Sarah E. Clark & Christopher E. Mulligan & Rachel C. Janssen & Lyndsey Babcock & Diana Ir & Bridget Young & Nancy Krebs & Dominick J. Lemas & Linda K. Johnson & Tiffany Weir & La, 2018. "The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06929-0
    DOI: 10.1038/s41467-018-06929-0
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    Cited by:

    1. Teresa Auguet & Laia Bertran & Andrea Barrientos-Riosalido & Blanca Fabregat & Beatriz Villar & Carmen Aguilar & Fàtima Sabench, 2022. "Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?," IJERPH, MDPI, vol. 19(20), pages 1-14, October.

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