Author
Listed:
- Eline Teirlinck
(University of Ghent
Centre for Nano- and Biophotonics)
- Ranhua Xiong
(University of Ghent
Centre for Nano- and Biophotonics)
- Toon Brans
(University of Ghent
Centre for Nano- and Biophotonics)
- Katrien Forier
(University of Ghent
Centre for Nano- and Biophotonics
Ghent University Hospital)
- Juan Fraire
(University of Ghent
Centre for Nano- and Biophotonics)
- Heleen Van Acker
(University of Ghent)
- Nele Matthijs
(University of Ghent)
- Riet De Rycke
(Ghent University
Ghent University)
- Stefaan C. De Smedt
(University of Ghent
Centre for Nano- and Biophotonics)
- Tom Coenye
(University of Ghent)
- Kevin Braeckmans
(University of Ghent
Centre for Nano- and Biophotonics
Université de Lille
Laboratoire de Physique des Lasers, Atomes et Molécules UMR 8523)
Abstract
Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic diffusion and more effective biofilm eradication.
Suggested Citation
Eline Teirlinck & Ranhua Xiong & Toon Brans & Katrien Forier & Juan Fraire & Heleen Van Acker & Nele Matthijs & Riet De Rycke & Stefaan C. De Smedt & Tom Coenye & Kevin Braeckmans, 2018.
"Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms,"
Nature Communications, Nature, vol. 9(1), pages 1-12, December.
Handle:
RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06884-w
DOI: 10.1038/s41467-018-06884-w
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