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Electrophysiological mechanisms of human memory consolidation

Author

Listed:
  • Hui Zhang

    (Ruhr University Bochum)

  • Juergen Fell

    (University of Bonn)

  • Nikolai Axmacher

    (Ruhr University Bochum)

Abstract

Consolidation stabilizes memory traces after initial encoding. Rodent studies suggest that memory consolidation depends on replay of stimulus-specific activity patterns during fast hippocampal “ripple” oscillations. Here, we measured replay in intracranial electroencephalography recordings in human epilepsy patients, and related replay to ripples. Stimulus-specific activity was identified using representational similarity analysis and then tracked during waking rest and sleep after encoding. Stimulus-specific gamma (30–90 Hz) activity during early (100–500 ms) and late (500–1200 ms) encoding is spontaneously reactivated during waking state and sleep, independent of later memory. Ripples during nREM sleep, but not during waking state, trigger replay of activity from the late time window specifically for remembered items. Ripple-triggered replay of activity from the early time window during nREM sleep is enhanced for forgotten items. These results provide the first electrophysiological evidence for replay related to memory consolidation in humans, and point to a prominent role of nREM ripple-triggered replay in consolidation processes.

Suggested Citation

  • Hui Zhang & Juergen Fell & Nikolai Axmacher, 2018. "Electrophysiological mechanisms of human memory consolidation," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06553-y
    DOI: 10.1038/s41467-018-06553-y
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    Cited by:

    1. Sanne Ten Oever & Alexander T. Sack & Carina R. Oehrn & Nikolai Axmacher, 2021. "An engram of intentionally forgotten information," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Haoxin Zhang & Ivan Skelin & Shiting Ma & Michelle Paff & Lilit Mnatsakanyan & Michael A. Yassa & Robert T. Knight & Jack J. Lin, 2024. "Awake ripples enhance emotional memory encoding in the human brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Ralf C. Buckley, 2022. "Sensory and Emotional Components in Tourist Memories of Wildlife Encounters: Intense, Detailed, and Long-Lasting Recollections of Individual Incidents," Sustainability, MDPI, vol. 14(8), pages 1-12, April.
    4. Kazuki Sakakura & Naoto Kuroda & Masaki Sonoda & Takumi Mitsuhashi & Ethan Firestone & Aimee F. Luat & Neena I. Marupudi & Sandeep Sood & Eishi Asano, 2023. "Developmental atlas of phase-amplitude coupling between physiologic high-frequency oscillations and slow waves," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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