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Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

Author

Listed:
  • Nhan T. Ho

    (Columbia University)

  • Fan Li

    (University of California)

  • Kathleen A. Lee-Sarwar

    (Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School)

  • Hein M. Tun

    (University of Alberta
    The University of Hong Kong)

  • Bryan P. Brown

    (Duke University
    Institute of Infectious Disease and Molecular Medicine
    University of Washington)

  • Pia S. Pannaraj

    (University of Southern California)

  • Jeffrey M. Bender

    (University of Southern California)

  • Meghan B. Azad

    (University of Manitoba)

  • Amanda L. Thompson

    (University of North Carolina)

  • Scott T. Weiss

    (Brigham and Women’s Hospital and Harvard Medical School)

  • M. Andrea Azcarate-Peril

    (University of North Carolina
    University of North Carolina)

  • Augusto A. Litonjua

    (University of Rochester Medical Center)

  • Anita L. Kozyrskyj

    (University of Alberta)

  • Heather B. Jaspan

    (Institute of Infectious Disease and Molecular Medicine
    University of Washington)

  • Grace M. Aldrovandi

    (University of California)

  • Louise Kuhn

    (Columbia University)

Abstract

Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.

Suggested Citation

  • Nhan T. Ho & Fan Li & Kathleen A. Lee-Sarwar & Hein M. Tun & Bryan P. Brown & Pia S. Pannaraj & Jeffrey M. Bender & Meghan B. Azad & Amanda L. Thompson & Scott T. Weiss & M. Andrea Azcarate-Peril & Au, 2018. "Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06473-x
    DOI: 10.1038/s41467-018-06473-x
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    Cited by:

    1. Huang Lin & Merete Eggesbø & Shyamal Das Peddada, 2022. "Linear and nonlinear correlation estimators unveil undescribed taxa interactions in microbiome data," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Shelly Jun & Kelsea Drall & Brittany Matenchuk & Cara McLean & Charlene Nielsen & Chinwe V. Obiakor & Aaron Van der Leek & Anita Kozyrskyj, 2018. "Sanitization of Early Life and Microbial Dysbiosis," Challenges, MDPI, vol. 9(2), pages 1-9, December.
    3. Yue Clare Lou & Benjamin E. Rubin & Marie C. Schoelmerich & Kaden S. DiMarco & Adair L. Borges & Rachel Rovinsky & Leo Song & Jennifer A. Doudna & Jillian F. Banfield, 2023. "Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2’-fucosyllactose utilization can be facilitated by coexisting species," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Alice Risely & Kerstin Wilhelm & Tim Clutton-Brock & Marta B. Manser & Simone Sommer, 2021. "Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Alan Le Goallec & Braden T Tierney & Jacob M Luber & Evan M Cofer & Aleksandar D Kostic & Chirag J Patel, 2020. "A systematic machine learning and data type comparison yields metagenomic predictors of infant age, sex, breastfeeding, antibiotic usage, country of origin, and delivery type," PLOS Computational Biology, Public Library of Science, vol. 16(5), pages 1-21, May.
    6. Jeong-Seon Lee & Jae Il Shin & Sunyeup Kim & Yong-Sung Choi & Youn Ho Shin & Jimin Hwang & Jung U Shin & Ai Koyanagi & Louis Jacob & Lee Smith & Han Eol Jeong & Yunha Noh & In-Sun Oh & Sang Youl Rhee , 2023. "Breastfeeding and impact on childhood hospital admissions: a nationwide birth cohort in South Korea," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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