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A deadly dance: the choreography of host–pathogen interactions, as revealed by single-cell technologies

Author

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  • Pratip K. Chattopadhyay

    (Precision Immunology, NYU Langone Health)

  • Mario Roederer

    (ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH)

  • Diane L. Bolton

    (US Military HIV Research Program, Henry M. Jackson Foundation, Walter Reed Army Institute of Research)

Abstract

Pathogens have numerous mechanisms by which they replicate within a host, who in turn responds by developing innate and adaptive immune countermeasures to limit disease. The advent of high-content single-cell technologies has facilitated a greater understanding of the properties of host cells harboring infection, the host’s pathogen-specific immune responses, and the mechanisms pathogens have evolved to escape host control. Here we review these advances and argue for greater inclusion of higher resolution single-cell technologies into approaches for defining immune evasion mechanisms by pathogens.

Suggested Citation

  • Pratip K. Chattopadhyay & Mario Roederer & Diane L. Bolton, 2018. "A deadly dance: the choreography of host–pathogen interactions, as revealed by single-cell technologies," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06214-0
    DOI: 10.1038/s41467-018-06214-0
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