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Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Author

Listed:
  • Greg J. Duncan

    (University of British Columbia (UBC)
    University of British Columbia)

  • Sohrab B. Manesh

    (University of British Columbia (UBC)
    University of British Columbia)

  • Brett J. Hilton

    (University of British Columbia (UBC)
    University of British Columbia
    Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE))

  • Peggy Assinck

    (University of British Columbia (UBC)
    University of British Columbia)

  • Jie Liu

    (University of British Columbia (UBC))

  • Aaron Moulson

    (University of British Columbia (UBC)
    University of British Columbia)

  • Jason R. Plemel

    (University of Calgary)

  • Wolfram Tetzlaff

    (University of British Columbia (UBC)
    University of British Columbia
    University of British Columbia)

Abstract

Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.

Suggested Citation

  • Greg J. Duncan & Sohrab B. Manesh & Brett J. Hilton & Peggy Assinck & Jie Liu & Aaron Moulson & Jason R. Plemel & Wolfram Tetzlaff, 2018. "Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05473-1
    DOI: 10.1038/s41467-018-05473-1
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    Cited by:

    1. Floriane Bretheau & Adrian Castellanos-Molina & Dominic Bélanger & Maxime Kusik & Benoit Mailhot & Ana Boisvert & Nicolas Vallières & Martine Lessard & Matthias Gunzer & Xiaoyu Liu & Éric Boilard & Ni, 2022. "The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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