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Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4

Author

Listed:
  • Dan Li

    (Huazhong University of Science and Technology)

  • Huajie Song

    (Huazhong University of Science and Technology)

  • Hong Mei

    (Huazhong University of Science and Technology)

  • Erhu Fang

    (Huazhong University of Science and Technology)

  • Xiaojing Wang

    (Huazhong University of Science and Technology)

  • Feng Yang

    (Huazhong University of Science and Technology)

  • Huanhuan Li

    (Huazhong University of Science and Technology)

  • Yajun Chen

    (Huazhong University of Science and Technology)

  • Kai Huang

    (Huazhong University of Science and Technology)

  • Liduan Zheng

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Qiangsong Tong

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Recent studies suggest the emerging roles of armadillo (ARM) family proteins in tumor progression. However, the functions and underlying mechanisms of ARM members in tumorigenesis and aggressiveness of neuroblastoma (NB) remain to be determined. Herein, we identify armadillo repeat containing 12 (ARMC12) as an ARM member associated with NB progression. ARMC12 promotes the growth and aggressiveness of NB cell lines. Mechanistically, ARMC12 physically interacts with retinoblastoma binding protein 4 (RBBP4) to facilitate the formation and activity of polycomb repressive complex 2, resulting in transcriptional repression of tumor suppressive genes. Blocking the interaction between ARMC12 and RBBP4 by cell-penetrating inhibitory peptide activates the downstream gene expression and suppresses the tumorigenesis and aggressiveness of NB cells. Both ARMC12 and RBBP4 are upregulated in NB tissues, and are associated with unfavorable outcome of patients. These findings suggest the crucial roles of ARMC12 in tumor progression and a potential therapeutic approach for NB.

Suggested Citation

  • Dan Li & Huajie Song & Hong Mei & Erhu Fang & Xiaojing Wang & Feng Yang & Huanhuan Li & Yajun Chen & Kai Huang & Liduan Zheng & Qiangsong Tong, 2018. "Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05286-2
    DOI: 10.1038/s41467-018-05286-2
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