IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05152-1.html
   My bibliography  Save this article

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

Author

Listed:
  • Anqi Geng

    (Beckman Research Institute of the City of Hope)

  • Runxiang Qiu

    (Beckman Research Institute of the City of Hope)

  • Kiyohito Murai

    (Beckman Research Institute of the City of Hope
    Nagasaki University School of Medicine)

  • Jiancheng Liu

    (Beckman Research Institute of the City of Hope)

  • Xiwei Wu

    (Beckman Research Institute of the City of Hope)

  • Heying Zhang

    (Beckman Research Institute of the City of Hope)

  • Henry Farhoodi

    (Beckman Research Institute of the City of Hope)

  • Nam Duong

    (Beckman Research Institute of the City of Hope)

  • Meisheng Jiang

    (University of California, Los Angeles)

  • Jiing-kuan Yee

    (Beckman Research Institute of the City of Hope)

  • Walter Tsark

    (Beckman Research Institute of the City of Hope)

  • Qiang Lu

    (Beckman Research Institute of the City of Hope)

Abstract

Balanced symmetric and asymmetric divisions of neural progenitor cells (NPCs) are crucial for brain development, but the underlying mechanisms are not fully understood. Here we report that mitotic kinesin KIF20A/MKLP2 interacts with RGS3 and plays a crucial role in controlling the division modes of NPCs during cortical neurogenesis. Knockdown of KIF20A in NPCs causes dislocation of RGS3 from the intercellular bridge (ICB), impairs the function of Ephrin-B–RGS cell fate signaling complex, and leads to a transition from proliferative to differentiative divisions. Germline and inducible knockout of KIF20A causes a loss of progenitor cells and neurons and results in thinner cortex and ventriculomegaly. Interestingly, loss of function of KIF20A induces early cell cycle exit and precocious neuronal differentiation without causing substantial cytokinesis defect or apoptosis. Our results identify a RGS–KIF20A axis in the regulation of cell division and suggest a potential link of the ICB to regulation of cell fate determination.

Suggested Citation

  • Anqi Geng & Runxiang Qiu & Kiyohito Murai & Jiancheng Liu & Xiwei Wu & Heying Zhang & Henry Farhoodi & Nam Duong & Meisheng Jiang & Jiing-kuan Yee & Walter Tsark & Qiang Lu, 2018. "KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05152-1
    DOI: 10.1038/s41467-018-05152-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05152-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05152-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05152-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.