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A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems

Author

Listed:
  • Yue Sun

    (Central China Normal University)

  • Fan Zhang

    (Central China Normal University)

  • Jiaxin Quan

    (Central China Normal University)

  • Fei Zhu

    (Central China Normal University)

  • Wei Hong

    (Central China Normal University)

  • Junkai Ma

    (Central China Normal University)

  • Huan Pang

    (Central China Normal University)

  • Yao Sun

    (Central China Normal University)

  • Demei Tian

    (Central China Normal University)

  • Haibing Li

    (Central China Normal University)

Abstract

Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host–guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantiomers and can be switched “off” by d-glucose and be switched “on” by l-glucose. Remarkably, the chiral nanochannel also exhibited a good reversibility toward glucose enantiomers. Further research indicates that the switching behaviors differed due to the differences in binding strength between chiral pillar[6]arene and glucose enantiomers, which can lead to the different surface charge within nanochannel. Given these promising results, the studies of chiral-driven ion gates may not only give interesting insight for the research of biological and pathological processes caused by glucose-sensitive ion channels, but also help to understand the origin of the high stereoselectivity in life systems.

Suggested Citation

  • Yue Sun & Fan Zhang & Jiaxin Quan & Fei Zhu & Wei Hong & Junkai Ma & Huan Pang & Yao Sun & Demei Tian & Haibing Li, 2018. "A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05103-w
    DOI: 10.1038/s41467-018-05103-w
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