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Single-breath-hold photoacoustic computed tomography of the breast

Author

Listed:
  • Li Lin

    (California Institute of Technology
    Washington University in St. Louis, One Brookings Dr.)

  • Peng Hu

    (Washington University in St. Louis, One Brookings Dr.)

  • Junhui Shi

    (California Institute of Technology)

  • Catherine M. Appleton

    (Breast Imaging Section, Washington University School of Medicine in St. Louis)

  • Konstantin Maslov

    (California Institute of Technology)

  • Lei Li

    (California Institute of Technology
    California Institute of Technology)

  • Ruiying Zhang

    (Washington University in St. Louis, One Brookings Dr.)

  • Lihong V. Wang

    (California Institute of Technology
    California Institute of Technology)

Abstract

We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts. SBH-PACT clearly reveals tumors by observing higher blood vessel densities associated with tumors at high spatial resolution, showing early promise for high sensitivity in radiographically dense breasts. In addition to blood vessel imaging, the high imaging speed enables dynamic studies, such as photoacoustic elastography, which identifies tumors by showing less compliance. We imaged breast cancer patients with breast sizes ranging from B cup to DD cup, and skin pigmentations ranging from light to dark. SBH-PACT identified all the tumors without resorting to ionizing radiation or exogenous contrast, posing no health risks.

Suggested Citation

  • Li Lin & Peng Hu & Junhui Shi & Catherine M. Appleton & Konstantin Maslov & Lei Li & Ruiying Zhang & Lihong V. Wang, 2018. "Single-breath-hold photoacoustic computed tomography of the breast," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04576-z
    DOI: 10.1038/s41467-018-04576-z
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    Cited by:

    1. Jingshun Pan & Qiang Li & Yaoming Feng & Ruifeng Zhong & Zhihao Fu & Shuixian Yang & Weiyuan Sun & Bin Zhang & Qi Sui & Jun Chen & Yuecheng Shen & Zhaohui Li, 2023. "Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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