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A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Author

Listed:
  • Hélène Choquet

    (Kaiser Permanente Northern California (KPNC))

  • Seyyedhassan Paylakhi

    (University of California San Francisco (UCSF))

  • Stephen C. Kneeland

    (Howard Hughes Medical Institute)

  • Khanh K. Thai

    (Kaiser Permanente Northern California (KPNC))

  • Thomas J. Hoffmann

    (UCSF
    UCSF)

  • Jie Yin

    (Kaiser Permanente Northern California (KPNC))

  • Mark N. Kvale

    (UCSF)

  • Yambazi Banda

    (UCSF)

  • Nicholas G. Tolman

    (Howard Hughes Medical Institute)

  • Pete A. Williams

    (Howard Hughes Medical Institute)

  • Catherine Schaefer

    (Kaiser Permanente Northern California (KPNC))

  • Ronald B. Melles

    (KPNC)

  • Neil Risch

    (Kaiser Permanente Northern California (KPNC)
    UCSF
    UCSF)

  • Simon W. M. John

    (Howard Hughes Medical Institute)

  • K. Saidas Nair

    (University of California San Francisco (UCSF)
    UCSF)

  • Eric Jorgenson

    (Kaiser Permanente Northern California (KPNC))

Abstract

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in African-Americans who have a higher risk for developing POAG. We conduct a multiethnic genome-wide association study (GWAS) of POAG in the GERA cohort, with replication in the UK Biobank (UKB), and vice versa, GWAS in UKB with replication in GERA. We identify 24 loci (P

Suggested Citation

  • Hélène Choquet & Seyyedhassan Paylakhi & Stephen C. Kneeland & Khanh K. Thai & Thomas J. Hoffmann & Jie Yin & Mark N. Kvale & Yambazi Banda & Nicholas G. Tolman & Pete A. Williams & Catherine Schaefer, 2018. "A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04555-4
    DOI: 10.1038/s41467-018-04555-4
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    Cited by:

    1. Danielle Rasooly & Gina M. Peloso & Alexandre C. Pereira & Hesam Dashti & Claudia Giambartolomei & Eleanor Wheeler & Nay Aung & Brian R. Ferolito & Maik Pietzner & Eric H. Farber-Eger & Quinn Stanton , 2023. "Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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