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Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme

Author

Listed:
  • Noriyuki Nishimura

    (National Agriculture and Food Research Organization
    National Agriculture and Food Research Organization)

  • Wataru Tsuchiya

    (National Agriculture and Food Research Organization)

  • James J. Moresco

    (The Scripps Research Institute)

  • Yuki Hayashi

    (Nagoya University)

  • Kouji Satoh

    (National Agriculture and Food Research Organization)

  • Nahomi Kaiwa

    (National Agriculture and Food Research Organization)

  • Tomoko Irisa

    (National Agriculture and Food Research Organization)

  • Toshinori Kinoshita

    (Nagoya University
    Nagoya University)

  • Julian I. Schroeder

    (University of California, San Diego)

  • John R. Yates

    (The Scripps Research Institute)

  • Takashi Hirayama

    (Okayama University)

  • Toshimasa Yamazaki

    (National Agriculture and Food Research Organization)

Abstract

Abscisic acid (ABA) regulates abiotic stress and developmental responses including regulation of seed dormancy to prevent seeds from germinating under unfavorable environmental conditions. ABA HYPERSENSITIVE GERMINATION1 (AHG1) encoding a type 2C protein phosphatase (PP2C) is a central negative regulator of ABA response in germination; however, the molecular function and regulation of AHG1 remain elusive. Here we report that AHG1 interacts with DELAY OF GERMINATION1 (DOG1), which is a pivotal positive regulator in seed dormancy. DOG1 acts upstream of AHG1 and impairs the PP2C activity of AHG1 in vitro. Furthermore, DOG1 has the ability to bind heme. Binding of DOG1 to AHG1 and heme are independent processes, but both are essential for DOG1 function in vivo. Our study demonstrates that AHG1 and DOG1 constitute an important regulatory system for seed dormancy and germination by integrating multiple environmental signals, in parallel with the PYL/RCAR ABA receptor-mediated regulatory system.

Suggested Citation

  • Noriyuki Nishimura & Wataru Tsuchiya & James J. Moresco & Yuki Hayashi & Kouji Satoh & Nahomi Kaiwa & Tomoko Irisa & Toshinori Kinoshita & Julian I. Schroeder & John R. Yates & Takashi Hirayama & Tosh, 2018. "Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04437-9
    DOI: 10.1038/s41467-018-04437-9
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    Cited by:

    1. Marina Gomtsyan & Céline Lévy-Leduc & Sarah Ouadah & Laure Sansonnet & Christophe Bailly & Loïc Rajjou, 2025. "Variable selection in sparse multivariate GLARMA models: application to germination control by environment," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 34(2), pages 291-324, May.
    2. Obroucheva NV & Lityagina SV & Sinkevich IA, 2019. "Distinct Pathways of Regulation Seed Dormancy and Germination by Abscisic Acid," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(4), pages 74-78, January.
    3. Sebastian Przemyslaw Sacharowski & Michal Krzyszton & Lien Brzezniak & Karol Jerzy Rogowski & Miguel Montez & Katarzyna Rosol & Magdalena Wrona & Ruslan Yatusevich & Veena Halale Manjunath & Lukasz Sz, 2025. "Chromatin retained MUSHER lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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