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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Author

Listed:
  • Minh Binh Nguyen

    (Icahn School of Medicine at Mount Sinai)

  • Idan Cohen

    (Icahn School of Medicine at Mount Sinai)

  • Vinod Kumar

    (University of Helsinki)

  • Zijian Xu

    (National Institute of Biological Sciences)

  • Carmit Bar

    (Icahn School of Medicine at Mount Sinai)

  • Katherine L. Dauber-Decker

    (Icahn School of Medicine at Mount Sinai)

  • Pai-Chi Tsai

    (Harvard Stem Cell Institute)

  • Pauline Marangoni

    (University of California San Francisco)

  • Ophir D. Klein

    (University of California San Francisco
    University of California San Francisco)

  • Ya-Chieh Hsu

    (Harvard Stem Cell Institute)

  • Ting Chen

    (National Institute of Biological Sciences)

  • Marja L. Mikkola

    (University of Helsinki)

  • Elena Ezhkova

    (Icahn School of Medicine at Mount Sinai)

Abstract

Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.

Suggested Citation

  • Minh Binh Nguyen & Idan Cohen & Vinod Kumar & Zijian Xu & Carmit Bar & Katherine L. Dauber-Decker & Pai-Chi Tsai & Pauline Marangoni & Ophir D. Klein & Ya-Chieh Hsu & Ting Chen & Marja L. Mikkola & El, 2018. "FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04399-y
    DOI: 10.1038/s41467-018-04399-y
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