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Supramolecular Kandinsky circles with high antibacterial activity

Author

Listed:
  • Heng Wang

    (University of South Florida)

  • Xiaomin Qian

    (University of South Florida
    Dalian University of Technology)

  • Kun Wang

    (University of Georgia)

  • Ma Su

    (University of South Florida)

  • Wei-Wei Haoyang

    (Fudan University)

  • Xin Jiang

    (Jilin University)

  • Robert Brzozowski

    (University of South Florida)

  • Ming Wang

    (Jilin University)

  • Xiang Gao

    (Zhengzhou University)

  • Yiming Li

    (University of South Florida)

  • Bingqian Xu

    (University of Georgia)

  • Prahathees Eswara

    (University of South Florida)

  • Xin-Qi Hao

    (Zhengzhou University)

  • Weitao Gong

    (Dalian University of Technology)

  • Jun-Li Hou

    (Fudan University)

  • Jianfeng Cai

    (University of South Florida)

  • Xiaopeng Li

    (University of South Florida)

Abstract

Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2−G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.

Suggested Citation

  • Heng Wang & Xiaomin Qian & Kun Wang & Ma Su & Wei-Wei Haoyang & Xin Jiang & Robert Brzozowski & Ming Wang & Xiang Gao & Yiming Li & Bingqian Xu & Prahathees Eswara & Xin-Qi Hao & Weitao Gong & Jun-Li , 2018. "Supramolecular Kandinsky circles with high antibacterial activity," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04247-z
    DOI: 10.1038/s41467-018-04247-z
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