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Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

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  • Niek Verweij

    (University of Groningen, University Medical Center Groningen, Department of Cardiology)

  • Yordi J. van de Vegte

    (University of Groningen, University Medical Center Groningen, Department of Cardiology)

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen, Department of Cardiology
    University of Groningen, University Medical Center Groningen, Department of Genetics
    ICIN - Netherlands Heart Institute)

Abstract

Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p

Suggested Citation

  • Niek Verweij & Yordi J. van de Vegte & Pim van der Harst, 2018. "Genetic study links components of the autonomous nervous system to heart-rate profile during exercise," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03395-6
    DOI: 10.1038/s41467-018-03395-6
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    Cited by:

    1. Yordi J. Vegte & Ruben N. Eppinga & M. Yldau Ende & Yanick P. Hagemeijer & Yuvaraj Mahendran & Elias Salfati & Albert V. Smith & Vanessa Y. Tan & Dan E. Arking & Ioanna Ntalla & Emil V. Appel & Claudi, 2023. "Genetic insights into resting heart rate and its role in cardiovascular disease," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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