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FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Author

Listed:
  • Ivo S. Hansen

    (University of Amsterdam
    University of Amsterdam)

  • Lisette Krabbendam

    (University of Amsterdam)

  • Jochem H. Bernink

    (University of Amsterdam)

  • Fabricio Loayza-Puch

    (Netherlands Cancer Institute)

  • Willianne Hoepel

    (University of Amsterdam
    University of Amsterdam)

  • Johan A. van Burgsteden

    (University of Amsterdam
    University of Amsterdam)

  • Elsa C. Kuijper

    (Leiden University Medical Centre, University of Leiden)

  • Christianne J. Buskens

    (University of Amsterdam)

  • Willem A. Bemelman

    (University of Amsterdam)

  • Sebastiaan A. J. Zaat

    (University of Amsterdam)

  • Reuven Agami

    (Netherlands Cancer Institute)

  • Gestur Vidarsson

    (University of Amsterdam)

  • Gijs R. van den Brink

    (University of Amsterdam)

  • Esther C. de Jong

    (University of Amsterdam)

  • Manon E. Wildenberg

    (University of Amsterdam)

  • Dominique L. P. Baeten

    (University of Amsterdam
    University of Amsterdam)

  • Bart Everts

    (Leiden University Medical Centre, University of Leiden)

  • Jeroen den Dunnen

    (University of Amsterdam
    University of Amsterdam)

Abstract

CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we show that immunoglobulin A (IgA) immune complexes (IgA-IC), which are present after bacterial infection of the lamina propria, are important for the induction of inflammation by the human CD103+SIRPα+ DC subset. IgA-IC, by recognition through FcαRI, selectively amplify the production of proinflammatory cytokines TNF, IL-1β and IL-23 by human CD103+ DCs. These cells then enhance inflammation by promoting Th17 responses and activating human intestinal innate lymphoid cells 3. Moreover, FcαRI-induced cytokine production is orchestrated via upregulation of cytokine translation and caspase-1 activation, which is dependent on glycolytic reprogramming mediated by kinases Syk, PI3K and TBK1-IKKε. Our data suggest that the formation of IgA-IC in the human intestine provides an environmental cue for the conversion of a tolerogenic to an inflammatory response.

Suggested Citation

  • Ivo S. Hansen & Lisette Krabbendam & Jochem H. Bernink & Fabricio Loayza-Puch & Willianne Hoepel & Johan A. van Burgsteden & Elsa C. Kuijper & Christianne J. Buskens & Willem A. Bemelman & Sebastiaan , 2018. "FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03318-5
    DOI: 10.1038/s41467-018-03318-5
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