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Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway

Author

Listed:
  • Vicente Balanzà

    (Consejo Superior de Investigaciones Científicas—Universidad Politécnica de Valencia)

  • Irene Martínez-Fernández

    (Consejo Superior de Investigaciones Científicas—Universidad Politécnica de Valencia)

  • Shusei Sato

    (University of California San Diego
    Tohoku University)

  • Martin F. Yanofsky

    (University of California San Diego)

  • Kerstin Kaufmann

    (Wageningen University & Research)

  • Gerco C. Angenent

    (Wageningen University & Research
    Wageningen University & Research)

  • Marian Bemer

    (Wageningen University & Research)

  • Cristina Ferrándiz

    (Consejo Superior de Investigaciones Científicas—Universidad Politécnica de Valencia)

Abstract

Monocarpic plants have a single reproductive cycle in their lives, where life span is determined by the coordinated arrest of all meristems, or global proliferative arrest (GPA). The molecular bases for GPA and the signaling mechanisms involved are poorly understood, other than systemic cues from developing seeds of unknown nature. Here we uncover a genetic pathway regulating GPA in Arabidopsis that responds to age-dependent factors and acts in parallel to seed-derived signals. We show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, as GPA is delayed and fruit production is increased in ful mutants. FUL directly and negatively regulates APETALA2 expression in the shoot apical meristem and maintains the temporal expression of WUSCHEL which is an essential factor for meristem maintenance.

Suggested Citation

  • Vicente Balanzà & Irene Martínez-Fernández & Shusei Sato & Martin F. Yanofsky & Kerstin Kaufmann & Gerco C. Angenent & Marian Bemer & Cristina Ferrándiz, 2018. "Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03067-5
    DOI: 10.1038/s41467-018-03067-5
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