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Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Author

Listed:
  • Xiao-Feng Li

    (Beijing Institute of Microbiology and Epidemiology
    Guangzhou Medical University)

  • Hao-Long Dong

    (Beijing Institute of Microbiology and Epidemiology)

  • Hong-Jiang Wang

    (Beijing Institute of Microbiology and Epidemiology
    Department of Infection Control)

  • Xing-Yao Huang

    (Beijing Institute of Microbiology and Epidemiology)

  • Ye-Feng Qiu

    (Academy of Military Medical Science)

  • Xue Ji

    (Beijing Institute of Microbiology and Epidemiology)

  • Qing Ye

    (Beijing Institute of Microbiology and Epidemiology
    Guangzhou Medical University)

  • Chunfeng Li

    (Beijing Institute of Microbiology and Epidemiology
    Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yang Liu

    (Tsinghua University)

  • Yong-Qiang Deng

    (Beijing Institute of Microbiology and Epidemiology)

  • Tao Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Gong Cheng

    (Tsinghua University)

  • Fu-Chun Zhang

    (Guangzhou Medical University)

  • Andrew D. Davidson

    (University of Bristol)

  • Ya-Jun Song

    (Beijing Institute of Microbiology and Epidemiology)

  • Pei-Yong Shi

    (University of Texas Medical Branch
    University of Texas Medical Branch)

  • Cheng-Feng Qin

    (Beijing Institute of Microbiology and Epidemiology
    Guangzhou Medical University)

Abstract

The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models. Remarkably, immunization of mice and rhesus macaques with a single dose of ChinZIKV elicits robust and long-lasting immune responses, and confers complete protection against ZIKV challenge. Significantly, female mice immunized with ChinZIKV are protected against placental and fetal damage upon ZIKV challenge during pregnancy. Overall, our study provides an alternative vaccine platform in response to the ZIKV emergency, and the safety, immunogenicity, and protection profiles of ChinZIKV warrant further clinical development.

Suggested Citation

  • Xiao-Feng Li & Hao-Long Dong & Hong-Jiang Wang & Xing-Yao Huang & Ye-Feng Qiu & Xue Ji & Qing Ye & Chunfeng Li & Yang Liu & Yong-Qiang Deng & Tao Jiang & Gong Cheng & Fu-Chun Zhang & Andrew D. Davidso, 2018. "Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02975-w
    DOI: 10.1038/s41467-018-02975-w
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