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Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Author

Listed:
  • Metehan Cifdaloz

    (Spanish National Cancer Research Center (CNIO))

  • Lisa Osterloh

    (Spanish National Cancer Research Center (CNIO))

  • Osvaldo Graña

    (Bioinformatics Unit, CNIO)

  • Erica Riveiro-Falkenbach

    (Universidad Complutense)

  • Pilar Ximénez-Embún

    (Proteomics Core Unit, CNIO)

  • Javier Muñoz

    (Proteomics Core Unit, CNIO)

  • Cristina Tejedo

    (Spanish National Cancer Research Center (CNIO))

  • Tonantzin G. Calvo

    (Spanish National Cancer Research Center (CNIO))

  • Panagiotis Karras

    (Spanish National Cancer Research Center (CNIO))

  • David Olmeda

    (Spanish National Cancer Research Center (CNIO))

  • Belén Miñana

    (The Barcelona Institute of Science and Technology)

  • Gonzalo Gómez-López

    (Bioinformatics Unit, CNIO)

  • Estela Cañon

    (Spanish National Cancer Research Center (CNIO))

  • Eduardo Eyras

    (Universidad Pompeu Fabra
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Haihong Guo

    (RWTH Aachen University)

  • Ferdinand Kappes

    (RWTH Aachen University
    Xi’an Jiaotong-Liverpool University)

  • Pablo L. Ortiz-Romero

    (Universidad Complutense)

  • Jose L. Rodríguez-Peralto

    (Universidad Complutense)

  • Diego Megías

    (Confocal Microscopy Unit, (CNIO))

  • Juan Valcárcel

    (The Barcelona Institute of Science and Technology
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • María S. Soengas

    (Spanish National Cancer Research Center (CNIO))

Abstract

Melanomas are well-known for their altered mRNA expression profiles. Yet, the specific contribution of mRNA binding proteins (mRBPs) to melanoma development remains unclear. Here we identify a cluster of melanoma-enriched genes under the control of CUGBP Elav-like family member 1 (CELF1). CELF1 was discovered with a distinct prognostic value in melanoma after mining the genomic landscape of the 692 known mRBPs across different cancer types. Genome-wide transcriptomic, proteomic, and RNA-immunoprecipitation studies, together with loss-of-function analyses in cell lines, and histopathological evaluation in clinical biopsies, revealed an intricate repertoire of CELF1-RNA interactors with minimal overlap with other malignancies. This systems approach uncovered the oncogene DEK as an unexpected target and downstream effector of CELF1. Importantly, CELF1 and DEK were found to represent early-induced melanoma genes and adverse indicators of overall patient survival. These results underscore novel roles of CELF1 in melanoma, illustrating tumor type-restricted functions of RBPs in cancer.

Suggested Citation

  • Metehan Cifdaloz & Lisa Osterloh & Osvaldo Graña & Erica Riveiro-Falkenbach & Pilar Ximénez-Embún & Javier Muñoz & Cristina Tejedo & Tonantzin G. Calvo & Panagiotis Karras & David Olmeda & Belén Miñan, 2017. "Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1," Nature Communications, Nature, vol. 8(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02353-y
    DOI: 10.1038/s41467-017-02353-y
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