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Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Author

Listed:
  • Laura Frangeul

    (University of Geneva)

  • Vassilis Kehayas

    (University of Geneva)

  • Jose V. Sanchez-Mut

    (Brain Mind Institute, School of Life Science, Ecole Polytechnique Fédérale de Lausanne)

  • Sabine Fièvre

    (University of Geneva)

  • K. Krishna-K

    (University of Geneva
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Gabrielle Pouchelon

    (University of Geneva
    Harvard Medical School)

  • Ludovic Telley

    (University of Geneva)

  • Camilla Bellone

    (University of Geneva)

  • Anthony Holtmaat

    (University of Geneva)

  • Johannes Gräff

    (Brain Mind Institute, School of Life Science, Ecole Polytechnique Fédérale de Lausanne)

  • Jeffrey D. Macklis

    (Center for Brain Science, Harvard University)

  • Denis Jabaudon

    (University of Geneva
    Clinic of Neurology, Geneva University Hospital)

Abstract

Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. Here, using genetic and surgical manipulations of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitability is a critical component of dendritic development. Using a combination of genetic approaches, we find that ablation of N-methyl-d-aspartate (NMDA) receptors during postnatal development leads to epigenetic repression of Kv1.1-type potassium channels, increased excitability, and impaired dendritic maturation. Lesions to whisker input pathways had similar effects. Overexpression of Kv1.1 was sufficient to enable dendritic maturation in the absence of sensory input. Thus, Kv1.1 acts to tune neuronal excitability and maintain it within a physiological range, allowing dendritic maturation to proceed. Together, these results reveal an input-dependent control over neuronal excitability and dendritic complexity in the development and plasticity of sensory pathways.

Suggested Citation

  • Laura Frangeul & Vassilis Kehayas & Jose V. Sanchez-Mut & Sabine Fièvre & K. Krishna-K & Gabrielle Pouchelon & Ludovic Telley & Camilla Bellone & Anthony Holtmaat & Johannes Gräff & Jeffrey D. Macklis, 2017. "Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02172-1
    DOI: 10.1038/s41467-017-02172-1
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