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Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota

Author

Listed:
  • Gregorio Iraola

    (Institut Pasteur Montevideo
    Facultad de Ciencias, Universidad de la República
    Wellcome Trust Sanger Institute)

  • Samuel C. Forster

    (Wellcome Trust Sanger Institute
    Hudson Institute of Medical Research
    Monash University)

  • Nitin Kumar

    (Wellcome Trust Sanger Institute)

  • Philippe Lehours

    (INSERM UMR1053, University of Bordeaux
    University of Bordeaux)

  • Sadjia Bekal

    (Institut National de Santé Publique du Québec
    Immunologie et Infectiologie, Université de Montréal)

  • Francisco J. García-Peña

    (Laboratorio Central de Veterinaria de Algete (MAGRAMA))

  • Fernando Paolicchi

    (EEA-INTA Balcarce)

  • Claudia Morsella

    (EEA-INTA Balcarce)

  • Helmut Hotzel

    (Institute of Bacterial Infections and Zoonoses)

  • Po-Ren Hsueh

    (National Taiwan University Hospital)

  • Ana Vidal

    (Animal and Plant Health Association (APHA))

  • Simon Lévesque

    (Institut National de Santé Publique du Québec)

  • Wataru Yamazaki

    (Faculty of Agriculture, University of Miyazaki)

  • Claudia Balzan

    (Universidade Federal de Santa Maria)

  • Agueda Vargas

    (Universidade Federal de Santa Maria)

  • Alessandra Piccirillo

    (University of Padova)

  • Bonnie Chaban

    (Health, Education and Engineering, University of the Sunshine Coast)

  • Janet E. Hill

    (University of Saskatchewan)

  • Laura Betancor

    (Facultad de Medicina, Universidad de la República)

  • Luis Collado

    (Facultad de Ciencias, Universidad Austral de Chile)

  • Isabelle Truyers

    (University of Edinburgh)

  • Anne C. Midwinter

    (Massey University)

  • Hatice T. Dagi

    (Faculty of Medicine, Selçuk University)

  • Francis Mégraud

    (INSERM UMR1053, University of Bordeaux
    University of Bordeaux)

  • Lucía Calleros

    (Facultad de Ciencias, Universidad de la República)

  • Ruben Pérez

    (Facultad de Ciencias, Universidad de la República)

  • Hugo Naya

    (Institut Pasteur Montevideo
    Facultad de Agronomía, Universidad de la República)

  • Trevor D. Lawley

    (Wellcome Trust Sanger Institute)

Abstract

Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have “jumped” into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.

Suggested Citation

  • Gregorio Iraola & Samuel C. Forster & Nitin Kumar & Philippe Lehours & Sadjia Bekal & Francisco J. García-Peña & Fernando Paolicchi & Claudia Morsella & Helmut Hotzel & Po-Ren Hsueh & Ana Vidal & Simo, 2017. "Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01449-9
    DOI: 10.1038/s41467-017-01449-9
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