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Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity

Author

Listed:
  • Bronner P. Gonçalves

    (London School of Hygiene & Tropical Medicine)

  • Melissa C. Kapulu

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme
    Nuffield Department of Clinical Medicine, University of Oxford)

  • Patrick Sawa

    (International Centre of Insect Physiology and Ecology)

  • Wamdaogo M. Guelbéogo

    (Centre National de Recherche et de Formation sur le Paludisme)

  • Alfred B. Tiono

    (Centre National de Recherche et de Formation sur le Paludisme)

  • Lynn Grignard

    (London School of Hygiene & Tropical Medicine)

  • Will Stone

    (London School of Hygiene & Tropical Medicine
    Radboud University Medical Center)

  • Joel Hellewell

    (Department of Infectious Disease Epidemiology, Imperial College London)

  • Kjerstin Lanke

    (Radboud University Medical Center)

  • Guido J. H. Bastiaens

    (Radboud University Medical Center)

  • John Bradley

    (London School of Hygiene & Tropical Medicine)

  • Issa Nébié

    (Centre National de Recherche et de Formation sur le Paludisme)

  • Joyce M. Ngoi

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme)

  • Robin Oriango

    (International Centre of Insect Physiology and Ecology)

  • Dora Mkabili

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme)

  • Maureen Nyaurah

    (International Centre of Insect Physiology and Ecology)

  • Janet Midega

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Dyann F. Wirth

    (Harvard T.H. Chan School of Public Health)

  • Kevin Marsh

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme
    Nuffield Department of Clinical Medicine, University of Oxford)

  • Thomas S. Churcher

    (Department of Infectious Disease Epidemiology, Imperial College London)

  • Philip Bejon

    (Kenya Medical Research Institute (KEMRI)-Wellcome Trust Programme
    Nuffield Department of Clinical Medicine, University of Oxford)

  • Sodiomon B. Sirima

    (Centre National de Recherche et de Formation sur le Paludisme)

  • Chris Drakeley

    (London School of Hygiene & Tropical Medicine)

  • Teun Bousema

    (London School of Hygiene & Tropical Medicine
    Radboud University Medical Center)

Abstract

A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both sites, we identified 39 infectious individuals. In high endemicity settings, infectious individuals were identifiable by research-grade microscopy (92.6%; 25/27), whilst one of three infectious individuals in the lowest endemicity setting was detected by molecular techniques alone. The percentages of infected mosquitoes in the different surveys ranged from 0.05 (4/7716) to 1.6% (121/7749), and correlate positively with transmission intensity. We also estimated exposure to malaria vectors through genetic matching of blood from 1094 wild-caught bloodfed mosquitoes with that of humans resident in the same houses. Although adults transmitted fewer parasites to mosquitoes than children, they received more mosquito bites, thus balancing their contribution to the infectious reservoir.

Suggested Citation

  • Bronner P. Gonçalves & Melissa C. Kapulu & Patrick Sawa & Wamdaogo M. Guelbéogo & Alfred B. Tiono & Lynn Grignard & Will Stone & Joel Hellewell & Kjerstin Lanke & Guido J. H. Bastiaens & John Bradley , 2017. "Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01270-4
    DOI: 10.1038/s41467-017-01270-4
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    Cited by:

    1. Gillian Stresman & Charlie Whittaker & Hannah C Slater & Teun Bousema & Jackie Cook, 2020. "Quantifying Plasmodium falciparum infections clustering within households to inform household-based intervention strategies for malaria control programs: An observational study and meta-analysis from ," PLOS Medicine, Public Library of Science, vol. 17(10), pages 1-17, October.

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