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Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator

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  • A. Chen

    (University of Toronto)

  • P. D. Arora

    (University of Toronto)

  • C. A. McCulloch

    (University of Toronto)

  • A. Wilde

    (University of Toronto
    University of Toronto)

Abstract

Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions.

Suggested Citation

  • A. Chen & P. D. Arora & C. A. McCulloch & A. Wilde, 2017. "Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01231-x
    DOI: 10.1038/s41467-017-01231-x
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