IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-00952-3.html
   My bibliography  Save this article

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Author

Listed:
  • Y. Anraku

    (The University of Tokyo)

  • H. Kuwahara

    (Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University (TMDU))

  • Y. Fukusato

    (The University of Tokyo)

  • A. Mizoguchi

    (The University of Tokyo)

  • T. Ishii

    (The University of Tokyo)

  • K. Nitta

    (Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University (TMDU))

  • Y. Matsumoto

    (The University of Tokyo
    The University of Tokyo)

  • K. Toh

    (Kawasaki Institute of Industrial Promotion)

  • K. Miyata

    (The University of Tokyo
    The University of Tokyo)

  • S. Uchida

    (The University of Tokyo
    The University of Tokyo)

  • K. Nishina

    (Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University (TMDU))

  • K. Osada

    (The University of Tokyo)

  • K. Itaka

    (The University of Tokyo)

  • N. Nishiyama

    (Tokyo Institute of Technology)

  • H. Mizusawa

    (Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University (TMDU))

  • T. Yamasoba

    (The University of Tokyo)

  • T. Yokota

    (Tokyo Medical and Dental University (TMDU)
    Tokyo Medical and Dental University (TMDU))

  • K. Kataoka

    (Kawasaki Institute of Industrial Promotion
    The University of Tokyo)

Abstract

Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.

Suggested Citation

  • Y. Anraku & H. Kuwahara & Y. Fukusato & A. Mizoguchi & T. Ishii & K. Nitta & Y. Matsumoto & K. Toh & K. Miyata & S. Uchida & K. Nishina & K. Osada & K. Itaka & N. Nishiyama & H. Mizusawa & T. Yamasoba, 2017. "Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00952-3
    DOI: 10.1038/s41467-017-00952-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-00952-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-00952-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00952-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.