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Quantitative structural mechanobiology of platelet-driven blood clot contraction

Author

Listed:
  • Oleg V. Kim

    (University of Pennsylvania School of Medicine
    University of Notre Dame
    Harper Cancer Research Institute
    University of California Riverside)

  • Rustem I. Litvinov

    (University of Pennsylvania School of Medicine
    Kazan Federal University)

  • Mark S. Alber

    (University of Notre Dame
    University of California Riverside
    Indiana University School of Medicine)

  • John W. Weisel

    (University of Pennsylvania School of Medicine)

Abstract

Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the level of single platelets. A key elementary step of contraction is sequential extension–retraction of platelet filopodia attached to fibrin fibers. In contrast to other cell–matrix systems in which cells migrate along fibers, the “hand-over-hand” longitudinal pulling causes shortening and bending of platelet-attached fibers, resulting in formation of fiber kinks. When attached to multiple fibers, platelets densify the fibrin network by pulling on fibers transversely to their longitudinal axes. Single platelets and aggregates use actomyosin contractile machinery and integrin-mediated adhesion to remodel the extracellular matrix, inducing compaction of fibrin into bundled agglomerates tightly associated with activated platelets. The revealed platelet-driven mechanisms of blood clot contraction demonstrate an important new biological application of cell motility principles.

Suggested Citation

  • Oleg V. Kim & Rustem I. Litvinov & Mark S. Alber & John W. Weisel, 2017. "Quantitative structural mechanobiology of platelet-driven blood clot contraction," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00885-x
    DOI: 10.1038/s41467-017-00885-x
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    Cited by:

    1. Sandra Mayr & Fabian Hauser & Sujitha Puthukodan & Markus Axmann & Janett Göhring & Jaroslaw Jacak, 2020. "Statistical analysis of 3D localisation microscopy images for quantification of membrane protein distributions in a platelet clot model," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-34, June.

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