IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15711.html
   My bibliography  Save this article

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

Author

Listed:
  • Todd Bradley

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Justin Pollara

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Sampa Santra

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Nathan Vandergrift

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Srivamshi Pittala

    (Dartmouth College)

  • Chris Bailey-Kellogg

    (Dartmouth College)

  • Xiaoying Shen

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Robert Parks

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Derrick Goodman

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Amanda Eaton

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Harikrishnan Balachandran

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Linh V. Mach

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Kevin O. Saunders

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Joshua A. Weiner

    (Dartmouth College)

  • Richard Scearce

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Laura L. Sutherland

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Sanjay Phogat

    (Sanofi Pasteur)

  • Jim Tartaglia

    (Sanofi Pasteur)

  • Steven G. Reed

    (Infectious Disease Research Institute)

  • Shiu-Lok Hu

    (University of Washington)

  • James F. Theis

    (Public Health Research Institute, New Jersey Medical School, Rutgers University)

  • Abraham Pinter

    (Public Health Research Institute, New Jersey Medical School, Rutgers University)

  • David C. Montefiori

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Thomas B. Kepler

    (Boston University)

  • Kristina K. Peachman

    (US Military HIV Research Program, Walter Reed Army Institute of Research
    Henry M. Jackson Foundation for the Advancement of Military Medicine)

  • Mangala Rao

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Nelson L. Michael

    (US Military HIV Research Program, Walter Reed Army Institute of Research)

  • Todd J. Suscovich

    (Ragon Institute of MGH, MIT, and Harvard)

  • Galit Alter

    (Ragon Institute of MGH, MIT, and Harvard)

  • Margaret E. Ackerman

    (Dartmouth College)

  • M. Anthony Moody

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Hua-Xin Liao

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Georgia Tomaras

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Guido Ferrari

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Bette T. Korber

    (Los Alamos National Laboratories)

  • Barton F. Haynes

    (Duke Human Vaccine Institute, Duke University Medical Center)

Abstract

The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine efficacy. Here we design an ALVAC/Pentavalent B/E/E/E/E vaccine to increase the diversity of gp120 motifs in the immunogen to elicit a broader antibody response and enhance protection. We find that immunization of rhesus macaques with the pentavalent vaccine results in protection of 55% of pentavalent-vaccine-immunized macaques from simian–human immunodeficiency virus (SHIV) challenge. Systems serology of the antibody responses identifies plasma antibody binding to HIV-infected cells, peak ADCC antibody titres, NK cell-mediated ADCC and antibody-mediated activation of MIP-1β in NK cells as the four immunological parameters that best predict decreased infection risk that are improved by the pentavalent vaccine. Thus inclusion of additional gp120 immunogens to a pox-prime/protein boost regimen can augment antibody responses and enhance protection from a SHIV challenge in rhesus macaques.

Suggested Citation

  • Todd Bradley & Justin Pollara & Sampa Santra & Nathan Vandergrift & Srivamshi Pittala & Chris Bailey-Kellogg & Xiaoying Shen & Robert Parks & Derrick Goodman & Amanda Eaton & Harikrishnan Balachandran, 2017. "Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge," Nature Communications, Nature, vol. 8(1), pages 1-15, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15711
    DOI: 10.1038/ncomms15711
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15711
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15711?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15711. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.